Speaker: Dr.Chao Cheng,Geisel School of Medicine at Dartmouth, USA Inviter: 交叉中心 Title: Transcriptional regulation inferred from ChIP-seq data Time & Venue: 2013.4.25 3:00pm S703 Abstract: Chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-seq) has been widely used to determine binding sites of transcription factors (TFs) and to investigate histone modifications in a genome wide scale. By integrating ChIP-seq data from the ENCODE project with other data sources such as expression data and TF binding motif information, we have developed new methods to identify TF target genes,to predict new human enhancers, to relate TF binding and histone modifications with gene expression, and to construct integrated human regulatory network. In this talk, I will explain these new methods and present some case studies.
